General Information

  • ID:  hor006016
  • Uniprot ID:  P85024
  • Protein name:  Bradykinin inhibitor peptide
  • Gene name:  NA
  • Organism:  Crotalus viridis viridis (Prairie rattlesnake)
  • Family:  Bradykinin inhibitor peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Crotalus viridis (species), Crotalus (genus), Crotalinae (subfamily), Viperidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera , Episquamata , Unidentata , Bifurcata , Squamata (order), Lepidosauria (class), Sauria , Sauropsida , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0090729 toxin activity
  • GO BP:  GO:0044498 envenomation resulting in modulation of blood pressure in another organism; GO:0044503 modulation of G protein-coupled receptor activity in another organism; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TPPAGPDVGPR
  • Length:  11(1-11)
  • Propeptide:  TPPAGPDVGPR
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Bradykinin inhibitor peptide antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (BDKRB2).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006016_AF2.pdbhor006016_ESM.pdb

Physical Information

Mass: 124172 Formula: C46H74N14O15
Absent amino acids: CEFHIKLMNQSWY Common amino acids: P
pI: 6.34 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -90 Boman Index: -1848
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 35.45
Instability Index: 2268.18 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  16277978
  • Title:  Identification and functional analysis of a novel bradykinin inhibitory peptide in the venoms of New World Crotalinae pit vipers.